学术报告 2023年06月30日（星期五）上午10:00 报告人：Prof. Inhwan  Hwang

题　目： Evolution of chloroplasts and mitochondria: a  new look through a window of the cellular system, protein targeting  mechanism
报告人： Prof. Inhwan Hwang
时　间： 2023年06月30日（星期五） 上午10:00
地　点：  中国农业大学  生命科学研究中心  一层报告厅

欢迎各位老师和同学踊跃参加！   植物抗逆高效全国重点实验室

Inhwan Hwang
Department of  Life Sciences, Pohang University of Science and Technology,  Korea

Abstract
One of most fascinating and  fundamental questions in biology is how the current form of eukaryotic cells has  arisen during evolution. Of these organelles, chloroplasts and mitochondria are  thought to be derived from two free-living bacteria, cyanobacterium and a-proteobacterium,  respectively. Phylogenetic analysis on the genetic materials of these organs was  powerful tool to reveal their origin. For their evolution, the most critical  event for successful endosymbiosis should have been the establishment of protein  targeting mechanisms from the host cells to the endosymbionts. Moreover, these  mechanisms should have been established after reflecting cellular conditions of  the host cell to ensure specific targeting of proteins to new organelles,  implying that protein targeting mechanisms may contain a clue to reveal the  evolutionary process of the target organelles. We have been studying the protein  targeting mechanisms to both chloroplasts and mitochondria. From this study, we  found the principle of targeting specificity determination of two types of  proteins, the interior and membrane anchored proteins. In this talk, I will  present evidence that the targeting signals of outer membrane proteins have a  hierarchical ranking of the ER, chloroplasts and mitochondria. For those  imported into organelles, I will present how the targeting specificity is  determined between chloroplasts and mitochondria. This kind of relationship in  the targeting signals was conserved among three different types of organisms,  animals, plants and yeasts.

 CV(Hwang).pdf