王良省，教授，博士生导师，2012年博士毕业于清华大学生命科学学院，2012-2020年先后在美国康奈尔大学博伊斯汤普逊研究所和德国慕尼黑大学生物系从事博士后研究，2020年以“杰出人才”引进中国农业大学，任生物学院教授。学术成果发表于PNAS、Plant Physiol、 Pant J、JIPB、Plant Sci等国际主流学术期刊，参与编写活性氧研究专著2本，主持国家自然科学基金面上项目1项目，担任Int J Mol Sci、Front Plant Sci编辑，参与PNAS、Plant Commun、New Phytol等学术期刊的同行评审工作。

活性氧(Reactive oxygen species, ROS)，尤其是单线态氧(singlet oxygen, ¹O₂),是植物叶绿体进行光合作用的必然副产物，也是造成叶绿体损伤最主要的原因。低浓度的ROS是维持多种生命活动（细胞分裂/分化、诱导开花等）所必须的。在多种胁迫条件下(高光、干旱、高/低温、生物/非生物损伤等)，叶绿体中会产生大量的ROS。过量的活性氧会激活信号转导级联反应、降低光合效率、抑制植物生长、引起细胞乃至整棵植株死亡。活性氧介导的、质体到细胞核的反向信号转导途径不仅参与维持质体的正常发育，而且协助质体整合多种环境信号，从而使质体能够对多种胁迫做出精确响应。

本实验室主要以模式植物拟南芥和农作物玉米为研究对象，以叶绿体为突破口，研究活性氧信号(特别是单线态氧信号)的产生、感知和信号转导过程，挖掘植物响应活性氧胁迫的关键基因，解析植物应对活性氧胁迫的新途径、新机制。使用的研究手段包括但不局限于遗传筛选、深度测序、电镜分析、代谢组学、蛋白组学、生物化学、细胞生物、分子生物学和植物生理学。

* = Corresponding author

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3. Wang L, Leister D, Kleine T* (2020). Chloroplast development and genomes uncoupled signaling are independent of the RdDM pathway. Scientific Reports. 10 (1): 15412. DOI:10.1038/s41598-020-71907-w

4. Wang L*, Leister D, Guan L, Zheng Y, Schneider K, Lehmann M, Apel K, Kleine T (2020). The Arabidopsis SAFEGUARD1 suppresses singlet oxygen-induced stress responses by protecting grana margins. Proceedings of the National Academy of Sciences of the United States of America. 117 (12): 6918-6927. DOI: 10.1073/pnas.1918640117

5. Wang L*, Kleine T (2020). Singlet oxygen and protochlorophyllide detection in Arabidopsis thaliana. In Reactive Oxygen Species: Methods and Protocols, Methods in Molecular Biology. 2202: 63-69. DOI: 10.1007/978-1-0716-0896-8_5

6. Wang L*, Apel K (2019). Dose-dependent effects of ¹O₂ in chloroplasts are determined by its timing and localization of production. Journal of Experimental Botany. 70:29-40. DOI: 10.1093/jxb/ery343

7. Lee K, Lehmann M, Paul MV, Wang L, Luckner M, Wanner G, Geigenberger P, Leister D, Kleine T* (2019). Lack of FIBRILLIN6 in Arabidopsis thaliana affects light acclimation and sulfate metabolism. New Phytologist. 16246. DOI: 10.1111/nph.16246

8. Sun L, Wang L, Zheng Z, Liu D* (2018). Identification and characterization of an Arabidopsis phosphate starvation-induced secreted acid phosphatase as a vegetative storage protein. Plant Science. 277: 278-284. DOI: 10.1016/j.plantsci.2018.09.016

9. Wang L, Liu D* (2018). Functions and regulation of phosphate starvation-induced secreted acid phosphatases in higher plants. Plant Science. 271: 108-116. DOI: 10.1016/j.plantsci.2018.03.013

10. Leister D, Wang L, Kleine T* (2017). Organellar gene expression and acclimation of plants to environmental stress. Frontiers in Plant Science. 8:387. doi: 10.3389/fpls.2017.00387

11. Wang L*, Liu D (2017). Analyses of root-secreted acid phosphatase activity in Arabidopsis. Bio-protocol. 7:7. DOI: 10.21769/BioProtoc.2202

12. Wang D, Liu H, Zhai G, Wang L, Shao J, Tao Y* (2016). OspTAC2 encodes a pentatricopeptide repeat protein and regulates rice chloroplast development. Journal of Genetics and Genomics. 43: 601-608. DOI: 10.1016/j.jgg.2016.09.002

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14. Wang L, Apel K* (2016) Chapter 39 Singlet Oxygen in Higher Plants. In Singlet Oxygen: Applications in Biosciences and Nanosciences, Vol 2. The Royal Society of Chemistry, pp 265-278.

15. Chen S, Kim C, Lee J, Lee H, Fei Z, Wang L, Apel K* (2015). Blocking the QB-binding site of photosystem II by tenuazonic acid, a non–host-specific toxin of Alternaria alternata, activates singlet oxygen-mediated and EXECUTER-dependent signaling in Arabidopsis. Plant, Cell & Environment. 38:1069–1080. DOI: 10.1111/pce.12462

16. Wang L, Lu S, Zhang Y, Liu D* (2014). Comparative genetic analysis of Arabidopsis purple acid phosphatases AtPAP10, AtPAP12, and AtPAP26 provides new insights into their roles in plant adaptation to phosphate deprivation. Journal of Integrative Plant Biology. 56: 299-314. DOI: 10.1111/jipb.12184

17. Wang L, Dong J, Gao Z, Liu D* (2012). The Arabidopsis gene HYPERSENSITIVE TO PHOSPHATE STARVATION 3 encodes ETHYLENE OVERPRODUCTION 1. Plant & cell physiology. 53(6): 1093–1105. DOI: 10.1093/pcp/pcs072

18. Wang L, Liu D* (2012). Arabidopsis purple acid phosphatase 10 is a component of plant adaptive mechanism to phosphate limitation. Plant signaling & behavior. 7:3 1-5. DOI: 10.4161/psb.19019

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