主要从事分子植物病毒学的基础理论及应用基础研究。近年来以大麦条纹花叶病毒 (BSMV) 为研究重点, 

1. 分析BSMV编码蛋白之间的相互作用、表达调控及其在病毒复制、移动和致病性中的作用；

2. BSMV编码蛋白的翻译后修饰及其功能分析；

3. BSMV与寄主植物相互作用的分子机制。

1.       Gerda Szakonyi, Joel M Guthridge, Dawei Li, Young Kendra, Michael V Holers, Xiaojiang S Chen, 2001, Structure of complement receptor 2 in complex with its C3d ligand, Science, 292: 1725-1728.

2.       Dawei Li, Rui Zhao, Wayne Lilyestrom, Dahai Gai, Rongguang Zhang, DeCaprio James, Ellen Fanning, Gerda Szakonyi, Xiaojiang S Chen, 2003, Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen, Nature, 423: 512-518.

3.       Dahai Gai, Rui Zhao, Dawei Li, Carla V Finkielstein, Xiaojiang S Chen, 2004, Mechanisms of conformational change for a replicative hexameric helicase of SV40 large T antigen, Cell, 119: 47-60.

4.       Lihua Guo, Yunhe Cao, Dawei Li, Shengniao Niu, Zhunan Cai, Chenggui Han, Yafeng Zhai, Jialin Yu, 2005, Analysis of nucleotide sequences and multimeric forms of a novel satellite RNA associated with Beet black scorch virus, Journal of Virology, 79: 3664-3674.

5.       Xuefeng Yuan, Yunhe Cao, Dehui Xi, Lihua Guo, Chenggui Han, Dawei Li*, Yafeng Zhai, Jialin Yu, 2006, Analysis of the subgenomic RNAs and the small ORFs of Beet black scorch virus by in vitro transcripts, Journal of General Virology, 78: 3077-3086.

6.       Montgomery T A, Howell M, Cuperus J T, Dawei Li, Alexander A, Chapman E J, Fahlgren N, Allen E, and James C Carrington, 2008, Specificity of ARGONAUTE7-miR390 interaction and dual functionality of ARGONAUTE7-miR390 complexes in TAS3 trans-acting siRNA formation, Cell, 133: 128-141.

7.       Yongliang Zhang, Jiang Li, Heng Pu, Jin Jin, Xiaofeng Zhang, Mingkuan Chen, Bin Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2010, Development of Tobacco necrosis virus A as a vector for efficient and stable expression of FMDV VP1 peptides, Plant Biotechnology Journal, 8(4): 506-523.

8.       Bo Zhou, Yongliang Zhang, Xianbing Wang, Jiangli Dong, Bin Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2010, Oral administration of plant-based rotavirus VP6 induces antigen-specific IgAs, IgGs and passive protection in mice, Vaccine, 28(37): 6021-6027.

9.       Yanjing Zhang, Xiaofeng Zhang, Shaofang Niu, Chenggui Han, Jialin Yu, Dawei Li*, 2011, Nuclear localization of Beet black scorch virus capsid protein and its interaction with importin a, Virus Research, 155(1): 307-315.

10.    Cheng Yuan⁺, Cui Li⁺, Lijie Yan, Andrew O Jackson, Zhiyong Liu, Chenggui Han, Jialin Yu, Dawei Li*, 2011, A high throughput Barley stripe mosaic virus vector for virus induced gene silencing in monocots and dicots, PLoS ONE, 6: e26468.

11.    Mi Yeon Lee⁺, Lijie Yan⁺, Florien A. Gorter, Brian Y.T. Kim, Yu Cui, Yue Hu, Cheng Yuan, Jessica Grindheim, Uma Ganesan, Zhiyong Liu, Chenggui Han, Jialin Yu, Dawei Li*, Andrew O. Jackson*, 2012, Brachypodium distachyon Bd3-1 resistance is elicited by the Barley stripe mosaic virus Triple Gene Block 1 movement protein. Journal of General Virology, 93(12): 2729-2739. (Cover story)

12.    Xiaofei Zhao, Xiaoling Wang, Kai Dong, Yongliang Zhang, Yue Hu, Xin Zhang, Yanmei Chen, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2015, Phosphorylation of Beet black scorch virus coat protein by PKA is required for the assembly and stability of virus particles. Scientific Reports, 5: 11585.

13.    Yue Hu⁺, Zhenggang Li⁺, Cheng Yuan, Xuejiao Jin, Lijie Yan, Xiaofei Zhao, Yongliang Zhang, Andrew O. Jackson, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2015, Phosphorylation of TGB1 by protein kinase CK2 promotes Barley stripe mosaic virusmovement in monocots and dicots, Journal of Experimental Botany, 66 (15): 4733-4747.

14.    Kun Zhang⁺, Yongliang Zhang⁺, Meng Yang, Songyu Liu, Zhenggang Li, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li^*, 2017, The Barley stripe mosaic virus γb protein promotes chloroplast-targeted replication by enhancing unwinding of RNA duplexes, PLoS Pathogens, 13(4): e1006319.

15.    Michael J. Adams, Scott Adkins, Claude Bragard, David Gilmer, Dawei Li, Stuart A. MacFarlane, Sek-Man Wong, Ulrich Melcher, Claudio Ratti, Ki Hyun Ryu, ICTV Report Consortium, 2017, ICTV virus taxonomy profile: Virgaviridae. Journal of General Virology, 98(8): 1999-2000.

16.    Meng Yang, Zhenggang Li, Kun Zhang, Xuan Zhang, Yongliang Zhang, Xianbing Wang, Chenggui Han, Jialin Yu, Kai Xu*, Dawei Li*, 2018, Barley stripe mosaic virus γb interacts with glycolate oxidase and inhibits peroxisomal ROS production to facilitate virus infection, Molecular Plant, 11(2): 338-341.

17.    Zhenggang Li, Yongliang Zhang, Zhihao Jiang, Xuejiao Jin, Kun Zhang, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2018, Hijacking of the nucleolar protein fibrillarin by TGB1 is required for cell-to-cell movement of Barley stripe mosaic virus, Molecular Plant Pathology, 19(5): 1222-1237 [ Recommended in F1000Prime: https://f1000.com/prime/731253032 ].

18.    Xuan Zhang, Kai Dong, Kai Xu, Kun Zhang, Xuejiao Jin, Meng Yang, Yongliang Zhang, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2018, Barley stripe mosaic virus infection requires PKA-mediated phosphorylation of γb for suppression of both RNA silencing and host cell death response, New Phytologist, 218(4): 1570-1585.

19.    Meng Yang, Yongliang Zhang, Xialin Xie, Ning Yue, Xianbing Wang, Chenggui Han, Jialin Yu, Yule Liu*, Dawei Li*, 2018, Barley stripe mosaic virus γb subverts autophagy to promote viral infection by disrupting the ATG7-ATG8 interaction, Plant Cell, 30 (7): 1582-1595.

20.   Zhihao Jiang, Meng Yang, Yongliang Zhang, Andrew O. Jackson, Dawei Li*, 2021, Hordeiviruses (Virgaviridae). In: Encyclopedia of Virology (Fourth Edition), Bamford D.H., Zuckerman M. (eds.) pp. 420-429. Academic Press: Oxford

21.   Xuan Zhang, Xueting Wang, Kai Xu, Zhihao Jiang, Kai Dong, Xialin Xie, He Zhang, Ning Yue, Yongliang Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, and Dawei Li*, 2021, The serine/threonine/tyrosine kinase STY46 defends against hordeivirus infection by phosphorylating γb protein, Plant Physiology, 186(1): 715-730. 

22.   Xueting Wang, Zhihao Jiang, Ning Yue, Xuejiao Jin, Xuan Zhang, Zhaolei Li, Yongliang Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, and Dawei Li*, 2021, Barley stripe mosaic virus γb protein disrupts chloroplast antioxidant defenses to optimize viral replication, EMBO Journal, 40(16): e107660.

23.   Meng Yang, Asigul Ismayil, Zhihao Jiang, Yan Wang, Xiyin Zheng, Yiguo Hong, Dawei Li*, Yule Liu*, 2022, A viral protein disrupts vacuolar acidification to facilitate virus infection in plants, EMBO Journal, 41(2): e108713. [Recommended by Faculty Opinions: https://facultyopinions.com/article/741325789 ]

24.   Zhihao Jiang⁺*, Xuejiao Jin⁺, Meng Yang⁺, Qinglin Pi, Qing Cao, Zhenggang Li, Yongliang Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, Dawei Li^*, 2022, Barley stripe mosaic virus γb protein targets thioredoxin h-type 1 to dampen salicylic acid-mediated defenses, Plant Physiology, 189(3): 1715-1727. [ News and Views: https://doi.org/10.1093/plphys/kiac169 ]

25.   Ning Yue, Zhihao Jiang, Xuan Zhang, Zhenggang Li, Xueting Wang, Zhiyan Wen, Zongyu Gao, Qinglin Pi, Yongliang Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, Dawei Li*, 2022, Palmitoylation of γb protein directs a dynamic switch between Barley stripe mosaic virus replication and movement, EMBO Journal, 41(13), e110060. [Recommended by Faculty Opinions: https://facultyopinions.com/article/742175268 ]

(* Corresponding author)