学习经历
2005.9 - 2010.6 中国农业大学 生物学院 微生物学 博士
2001.9 - 2005.6 山东师范大学 生命科学学院 生物技术 学士
工作经历
2019.12 - 今 中国农业大学 生物学院 教授
2014.01 - 2019.11 中国农业大学 生物学院 副教授
2010.07 - 2013.12 中国农业大学 生物学院 讲师
2017.08 - 2018.10 加州大学戴维斯分校 (UC Davis) 访问学者
2013.03 - 2013.08 加州大学伯克利分校 (UC Berkeley) 访问学者
植物病毒严重威胁世界农业生产和粮食安全。这其中有一类称之为正义链RNA病毒, 正义链RNA病毒占病毒总数的1/3以上, 如2020年爆发并肆虐全球的新型冠状病毒。此外, 在植物病毒领域评选出的最重要的10个植物病毒中, 有7个是正义链RNA病毒。因此, 研究正义链RNA病毒与宿主互作的分子机制对于病毒病害防控具有重要的科学意义, 可为抗病毒策略的开发提供潜在的靶点。本研究组以甜菜黑色焦枯病毒 (BBSV) 和大麦条纹花叶病毒 (BSMV) 为代表的植物正义链RNA病毒为研究对象, 围绕植物病毒与宿主互作 (Plant-virus interaction) 开展研究, 主要包括以下3个研究方向 (基础 + 应用):
1. 植物病毒侵染和致病的分子机制。研究病毒如何增殖和扩散及反防御寄主免疫, 为植物重要病毒病害绿色防控提供理论参考。
2. R基因介导的抗病毒免疫。以经典的N基因和首例禾本科植物BSR1抗性基因为模式, 研究R基因介导的抗病毒免疫信号转导, 为抗病分子设计育种提供理论依据。
3. 植物病毒载体的开发和利用。将植物病毒“变害为宝”, 开发基于植物病毒的表达载体、沉默载体和基因编辑载体, 以用于药用蛋白表达和植物功能基因研究。
部分发表论文 (*通讯作者, #同等贡献)
详见https://orcid.org/0000-0002-6790-1044
2023
1. Dingliang Zhang, Zongyu Gao, He Zhang, Yizhou Yang, Xinxin Yang, Xiaofei Zhao, Hailong Guo, Ugrappa Nagalakshmi, Dawei Li, Savithramma P. Dinesh-Kumar*, Yongliang Zhang*. The MAPK-Alfin-like 7 module negatively regulates ROS scavenging genes to promote NLR-mediated immunity. PNAS, 2023, 120(3): e2214750120. (Trends in Plant Science杂志Spotlight专文介绍, https://www.cell.com/trends/plant-science/fulltext/S1360-1385(23)00049-3).
2. Qianshen Zhang#, Zhiyan Wen#, Xin Zhang#, Jiajie She, Xiaoling Wang, Zongyu Gao, Ruiqi Wang, Xiaofei Zhao, Zhen Su, Zhen Li, Dawei Li, Xiaofeng Wang, Yongliang Zhang*. RETICULON-LIKE PROTEIN B2 is a pro-viral factor co-opted for the biogenesis of viral replication organelles in plants. Plant Cell, 2023, https://doi.org/10.1093/plcell/koad146.
3. Jianguo Wu#, Yongliang Zhang#, Fangfang Li#, Xiaoming Zhang#, Jian Ye, Taiyun Wei, Zhenghe Li, Xiaorong Tao, Feng Cui, Xianbing Wang, Lili Zhang, Fei Yan, Shifang Li, Yule Liu, Dawei Li, Xueping Zhou*, Yi Li*. Plant virology in the 21st century in China: Recent advances and future directions. Journal of Integrative Plant Biology., DOI: 10.1111/jipb.13580.
2022
4. Qiuhong Wu#, Yu Cui#, Xuejiao Jin#, Guoxin Wang#, Lijie Yan#, Chenchen Zhong, Meihua Yu, Wenli Li, Yong Wang, Ling Wang, Hao Wang, Chen Dang, Xinyu Zhang, Yongxing Chen, Panpan Zhang, Xiaofei Zhao, Jiajie Wu, Daolin Fu, Lanqin Xia, Eviatar Nevo, John Vogel, Naxin Huo, Dawei Li, Yong Q. Gu, Andrew O. Jackson*, Yongliang Zhang*, and Zhiyong Liu*. The CC‐NB‐LRR protein BSR1 from Brachypodium confers resistance to Barley stripe mosaic virus in gramineous plants by recognizing TGB1 movement protein. New Phytologist, 2022, 236: 2233-2248.
5. Zongyu Gao, Dingliang Zhang, Xiaoling Wang, Xin Zhang, Zhiyan Wen, Qianshen Zhang, Dawei Li, Savithramma P. Dinesh-Kumar, Yongliang Zhang*. Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants. Nature Communications, 2022, 13:716. (Editors’ Highlight; Web of Science高被引论文).
6. Zhaolei Li#, Xinxin Yang#, Wenli Li, Zhiyan Wen, Jiangning Duan, Zhihao Jiang, Dingliang Zhang, Xialin Xie, Xueting Wang, Fangfang Li, Dawei Li, Yongliang Zhang*. SAMDC3 enhances resistance to Barley stripe mosaic virus by promoting the ubiquitination and proteasomal degradation of viral γb protein. New Phytologist, 2022, 234: 618-633.
2021年以前
7. Yongliang Zhang*, Gaoyuan Song, Neeraj K. Lal, Ugrappa Nagalakshmi, Yuanyuan Li, Wenjie Zheng, Pin-jui Huang, Tess C. Branon, Alice Y. Ting, Justin W. Walley* and Savithramma P. Dinesh-Kumar*. TurboID-based proximity labeling reveals that UBR7 is a regulator of N NLR immune receptor-mediated immunity. Nature Communications, 2019, 10: 3252. (F1000Prime推荐; Web of Science高被引论文).
8. Tingdong Li#, Jiacheng Hu#, Yu Sun, Boshu Li, Dingliang Zhang, Wenli Li, Jinxing Liu, Dawei Li, Caixia Gao, Yongliang Zhang*, Yanpeng Wang*. Highly efficient heritable genome editing in wheat using an RNA virus and bypassing tissue culture. Molecular Plant, 2021, 14: 1787-1798. (入选Molecular Plant 2021年度最佳论文; Web of Science高被引论文、热点论文)
9. Xinxin Yang#, Zhiyan Wen#, Dingliang Zhang, Zhen Li, Dawei Li, Ugrappa Nagalakshmi, Savithramma P. Dinesh-Kumar*, Yongliang Zhang*. Proximity labeling: An emerging tool for probing in planta molecular interactions, Plant Communications, 2021, 2: 100137. (入选Plant Communications 2021年度最佳论文)
10. Zhihao Jiang, Kun Zhang, Zhaolei Li, Zhenggang Li, Meng Yang, Xuejiao Jin, Qing Cao, Xueting Wang, Ning Yue, Dawei Li, Yongliang Zhang*. The Barley stripe mosaic virus γb protein promotes viral cell-to-cell movement by enhancing ATPase-mediated assembly of ribonucleoprotein movement complexes. PLoS Pathogens, 2020, 16(7): e1008709.
11. Kun Zhang#, Yongliang Zhang#, Meng Yang, Songyu Liu, Zhenggang Li, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li*. The Barley stripe mosaic virus γb protein promotes chloroplast-targeted replication by enhancing unwinding of RNA duplexes. PLoS Pathogens, 2017, 13(4): e1006319.
12. Xuejiao Jin, Zhihao Jiang, Kun Zhang, Pengfei Wang, Xiuling Cao, Ning Yue, Xueting Wang, Xuan Zhang, Yunqin Li, Dawei Li, Byung-Ho Kang, and Yongliang Zhang*. Three-dimensional analysis of chloroplast structures associated with virus infection. Plant Physiology, 2018, 176: 282-294.
13. Xiuling Cao, Xuejiao Jin, Xiaofeng Zhang, Ying Li, Chunyan Wang, Xianbing Wang, Jian Hong, Xiaofeng Wang, Dawei Li, Yongliang Zhang*. Morphogenesis of the ER membrane-invaginated vesicles during Beet black scorch virus infection: The role of auxiliary replication protein and new implications of three-dimensional architecture. Journal of Virology, 2015, 89(12): 6184-6195. (亮点文章).
14. Yongliang Zhang, Jiang Li, Heng Pu, Jin Jin, Xiaofeng Zhang, Mingkuan Chen, Bin Wang, Chenggui Han, Jialin Yu, Dawei Li. Development of Tobacco necrosis virus A as a vector for efficient and stable expression of FMDV VP1 peptides. Plant Biotechnology Journal, 2010, 8(4): 506-523.
15. Xueting Wang, Juncai Ma, Xuejiao Jin, Ning Yue, Peng Gao, Keith Ka Ki Mai, Xian-Bing Wang, Dawei Li, Byung-Ho Kang* and Yongliang Zhang*. Three-dimensional reconstruction and comparisons of vacuolar membranes associated with virus infections. Journal of Integrative Plant Biology, 2021, 63(2): 353–364. (封面文章)
16. Zongyu Gao, Heng Pu, Jingyuan Liu, Xiaoling Wang, Chenchen Zhong, Ning Yue, Ziding Zhang, Xian-Bing Wang, Chenggui Han, Jialin Yu, Dawei Li, Yongliang Zhang*. Tobacco necrosis virus-AC single coat protein amino acid substitutions determine host-specific systemic infections of Nicotiana benthamiana and soybean. Molecular Plant-Microbe Interactions, 2021, 34(1): 49–61. (亮点文章)
17. Deshui Liu#, Lindan Shi#, Chenggui Han, Jialin Yu, Dawei Li, Yongliang Zhang*. Validation of reference genes for gene expression studies in virus-infected Nicotiana benthamiana using quantitative real-time PCR. PLoS ONE, 2012, 7(9): e46451. (Web of Science高被引论文).
