宋文 教授，博士生导师。植物抗逆高效全国重点实验室课题组长。入选海外高层次人才计划。2018年博士毕业于清华大学，获理学博士学位。2018年-2023年在德国马克斯-普朗克研究所和科隆大学从事博士后研究。2023年以“杰出人才”引进中国农业大学，任生物学院教授。近年来，以（共同）第一作者/通讯作者在Nature, Cell, Science, Cell Research，Nature Plants, Nature Structural & Molecular Biology, Molecular Plant, Nature Communications等国际学术期刊上发表研究论文。
学习与工作经历
教育背景
2009.09-2013.06 中国农业大学，农学与生物技术学院，学士
2013.09-2018.06 清华大学，生命科学学院，博士
2017.08-2018.04 德国科隆大学，生物化学研究所，访问博士
工作经历
2018.08-2023.07 德国马克斯-普朗克植物育种研究所，科隆大学生物化学研究所，博士后
2023.08-至今 中国农业大学，生物学院，教授
实验室研究关注植物与微生物、植物与环境的互作。以生物化学、结构生物学和遗传学为手段，探究植物受体介导的免疫反应和非生物胁迫应答的分子机制。同时实验室也致力于利用结构生物学和基因编辑技术来设计改造植物关键蛋白，从而提高作物的广谱抗病性和环境适应能力。
（*Co-first author, #Corresponding author）
2024
1. Song W*, Liu L*, Yu D, Bernard H, Jirschitzka J, Hang S, Jia A, Jemleniak W, Acker J, Laessle H, Wang J, Shen Q, Chen W, Li P, Parker J, Han Z, Schulze-Lefert P, Chai J. (2024) Substrate-induced condensation activates plant TIR domain proteins. Nature
2023
2. Chai J, Song W, Parker J. (2023) New biochemical principles for NLR immunity in plants. MPMI (H. H. FLOR DISTINGUISHED REVIEW) 36 (8), 468-475
3. Yu Y*, Song W*, Zhai N*, Zhang S, Wang J, Wang S, Liu W, Huang C, Ma H, Chai J, Chang F. (2023) PXL1 and SERKs act as receptor–coreceptor complexes for the CLE19 peptide to regulate pollen development. Nature communications 14 (1), 3307
4. Wang J#, Song W#, Chai J#. (2023) Structure, biochemical function and signaling mechanism of plant NLRs. Molecular Plant 16 (1), 75-95
2022
5. Liu L*, Song W*, Huang S, Jiang K, Moriwaki Y, Wang Y, Men Y, Zhang D, Wen X, Han Z, Chai J, Guo H. (2022) Extracellular pH sensing by plant cell-surface peptide receptor complexes. Cell 185 (18), 3341-3355. e13
6. Yu D*, Song W*, Tan E *, Liu L, Cao Yu, Jirschitzka J, Li E, Logemann E, Xu C, Huang S, Jia A, Chang X, Han Z, Wu B, Schulze-Lefert P, Chai J. (2022) TIR domains of plant immune receptors are 2′, 3′-cAMP/cGMP synthetases mediating cell death. Cell 185 (13), 2370-2386. e18
7. Jia A*, Huang S*, Song W*, Wang J*, Meng Y*, Sun Y*, Xu L, Laessle H, Jirschitzka J, Hou J, Zhang T, Yu W, Hessler G, Li E, Ma S, Yu D, Gebauer J, Baumann U, Liu X, Han Z, Chang J, Parker J, Chai J. (2022) TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science 377 (6605), eabq8180.
8. Huang S*, Jia A*, Song W*, Hessler G*, Meng Y*, Sun Y, Xu L, Laessle H, Jirschitzka J, Ma S, Xiao Y, Yu D, Hou J, Liu R, Sun H, Liu X, Han Z, Chang J, Parker J, Chai J. (2022) Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science 377 (6605), eabq3297
9. Qian P*, Song W*, Zaizen-Iida M, Kume S, Wang G, Zhang Y, Chai J, and Kakimoto T. (2022) A Dof-CLE circuit controls phloem organization. Nature Plants 8 (7):817-827
10. Gao H, Song W, Severing E, Vayssières A, Huettel B, Franzen R, Richter R, Chai J, Coupland G. (2022) PIF4 enhances DNA binding by CDF2 to co-regulate target gene expression and promote Arabidopsis hypocotyl cell elongation. Nature Plants 8 (9), 1082-1093
2021
11. Song W*, Forderer A*, Yu D*, Chai J. (2021) Structural biology of plant defence. New Phytologist 229 (2), 692-711
2020
12. Ma S*, Lapin D*, Liu L*, Sun Y*, Song W*, Zhang X, Logemann E, Yu D, Wang J, Jirschitzka J, Han Z, Schulze-Lefert P, Parker JE, Chai J. (2020) Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science 370 (6521), eabe3069
2019
13. Zhu Y, Li H, Su Q, Wen J, Wang Y, Song W, Xie Y, He W, Yang Z, Jiang K, Guo H. (2019) A phenotype-directed chemical screen identifies ponalrestat as an inhibitor of the plant flavin monooxygenase YUCCA in auxin biosynthesis. Journal of Biological Chemistry 294 (52), 19923-19933
2018
14. Qian P*, Song W*, Yokoo T, Minobe A, Wang G, Ishida T, Sawa S, Chai J, Kakimoto T. (2018) The CLE9/10 secretory peptide regulates stomatal and vascular development through distinct receptors. Nature Plants 4 (12), 1071-1081
2017
15. Song W, Han Z, Wang J, Lin G, Chai J. (2017) Structural insights into ligand recognition and activation of plant receptor kinases. Current Opinion in Structural Biology 43, 18-27
16. Wu Z*, Liang S*, Song W*, Lin G, Wang W, Zhang H, Han Z, Chai J. (2017) Functional and structural characterization of a receptor-like kinase involved in germination and cell expansion in Arabidopsis. Frontiers in Plant Science 8, 1999
2016
17. Song W*, Liu L*, Wang J, Wu Z, Zhang H, Tang J, Lin G, Wang Y, Wen X, Li W, Han Z, Guo H, Chai J. (2016) Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Research 26 (6), 674-685
18. Zhang H, Han Z, Song W, Chai J. Structural insight into recognition of plant peptide hormones by receptors. (2016) Molecular Plant 9 (11), 1454-1463
2015
19. Song W*, Wang J*, Han Z*, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J, Wang HW, Chai J. (2015) Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nature Structural & Molecular Biology 22 (10), 782-787
20. Wang J, Wang W, Song W, Han Z, Zhang H, Chai J, Wang H, Wang J. (2015) An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data. Protein & Cell (12), 919-923
2014
21. Song W, Han Z, Sun Y, Chai J. (2014) Crystal structure of a plant leucine rich repeat protein with two island domains. Science China Life Sciences 57 (1), 137-144
22. Song W, Liu L, Li P, Sun H, Qin Y. (2014) Analysis of the mating and reproductive traits of Plutella xylostella (Lepidoptera: Plutellidae). Journal of Insect Science 14 (1)
2013
23. Song W, Li H, Song F, Liu L, Wang P, Xun H, Dai X, Chang J, Cai W. (2013) The complete mitochondrial genome of a tessaratomid bug, Eusthenes cupreus (Hemiptera: Heteroptera: Pentatomomorpha: Tessaratomidae). Zootaxa 3620 (2), 260-272
