随着全球气候变暖，高温胁迫严重影响植物的生长发育及作物产量。我们主要通过遗传学、分子生物化学和各种组学方法挖掘植物关键耐高温基因，解析植物感知和应答高温胁迫的分子机制，为培育抗高温作物新品种提供重要的基因资源和理论基础。
(*Corresponding author; #These authors contributed equally)
1. Wang X#, Zhang X#, Song C, Gong Z, Yang S, Ding Y* (2023) PUB25 and PUB26 dynamically modulate ICE1 stability via differential ubiquitination during cold stress in Arabidopsis. Plant Cell 35:3585-3603
2. Sun Z, Feng Z, Ding Y, Qi Y, Jiang S, Li Z, Wang Y, Qi J, Song C, Yang S, Gong Z* (2022) RAF22, ABI1 and OST1 form a dynamic interactive network that optimizes plant growth and responses to drought stress in Arabidopsis. Mol Plant 7:1192-1210
3. Ding Y*, Yang S* (2022) Surviving and thriving: How plants perceive and respond to temperature stress. Dev Cell 57:947-958 (Highly cited in ESI)
4. Ding Y*#, Yang H#, Wu S, Fu D, Li M, Gong Z, Yang S* (2022) CPK28-NLP7 module integrates cold-induced Ca2+ signal and transcriptional reprogramming in Arabidopsis. Sci Adv 8:eabn7901 (Selected for F1000 Prime; Highlighted with a Spotlight article in Nat Plants)
5. Chen R#, Deng Y#, Ding Y#, Guo J#, Qiu J#, Wang B#, Wang C#, Xie Y#, Zhang Z#, Chen J, Chen L, Chu C, He G, He Z, Huang Y, Xing Y, Yang S, Xie D*, Liu YG*, Li J* (2021) Rice functional genomics: decades’ efforts and roads ahead. Sci China Life Sci 65: 33-92. (Highly cited in ESI)
6. Song Y#, Zhang X#, Li M#, Yang H, Fu D, Lv J, Ding Y, Gong Z, Shi Y*, Yang S (2021) The direct targets of CBFs: in cold stress response and beyond. J Integr Plant Biol 63:1874-1887. (Highly cited in ESI)
7. Lv J, Liu J, Ming Y, Shi Y, Song C, Gong Z, Yang S, Ding Y* (2021) Reciprocal regulation between the negative regulator PP2CG1 phosphatase and the positive regulator OST1 kinase confers cold response in Arabidopsis. J Integr Plant Biol 63: 1568-1587.
8. Chen X#, Ding Y#, Yang Y#, Song C, Wang B, Yang S, Guo Y, Gong Z* (2021) Protein kinases in plant responses to drought, salt, and cold stress. J Integr Plant Biol 63: 53-78. (Highly cited in ESI)
9. Liu Q, Ding Y, Shi Y, Ma L, Wang Y, Song C, Wilkins KA, Davies JM, Knight H, Knight MR, Gong Z, Guo Y, Yang S* (2021) The calcium transporter ANNEXIN1 mediates cold-induced calcium signaling and freezing tolerance in plants. EMBO J 40: e104559. (Selected for F1000 Prime)
10. Gong Z#, Xiong L#, Shi H#, Yang S#, Herrera-Estrella LR#, Xu G#, Chao DY#, Li J, Wang PY, Qin F, Li J, Ding Y, Shi Y, Wang Y, Yang Y, Guo Y*, Zhu JK* (2020) Plant abiotic stress response and nutrient use efficiency. Sci China Life Sci 63, 635-674. (Highly cited in ESI)
11. Ding Y, Shi Y, Yang S* (2020) Molecular regulation of plant responses to environmental temperatures. Mol Plant13:544-564. (Highly cited in ESI)
12. Ye K#, Li H#, Ding Y, Shi Y, Song C, Gong Z, Yang S* (2019) BIN2 negatively regulates ICE1 stability in response to cold stress in Arabidopsis. Plant Cell 31: 2682-2696. (Highly cited in ESI)
13. Wang X, Ding Y, Li Z, Shi Y, Wang J, Hua J, Gong Z, Zhou JM, Yang S* (2019) PUB25 and PUB26 promote plant freezing tolerance by degrading the cold signaling negative regulator MYB15. Dev Cell 51: 222-235. (Selected for F1000 Prime)
14. Ding Y, Lv J, Shi Y, Gao J, Hua J, Song C, Gong Z, Yang S* (2019) EGR2 phosphatase regulates OST1 kinase activity and freezing tolerance in Arabidopsis. EMBO J 38: e99819. (Selected for F1000 Prime)
15. Ding Y#, Shi Y#, Yang S* (2019) Advances and challenges in uncovering cold tolerance regulatory mechanisms in plants. New Phytol 222: 1690-1704. (Highly cited in ESI)
16. Shi Y#, Ding Y#, Yang S* (2018) Molecular regulation of CBF signaling in cold acclimation. Trends Plant Sci 23: 623-637. (Highly cited in ESI)
17. Ding Y, Jia Y, Shi Y, Song C, Gong Z, Yang S* (2018) OST1-mediated BTF3L phosphorylation positively regulates CBFs during plant cold responses. EMBO J 37: e98228.
18. Wang K#, He J#, Zhao Y, Wu T, Zhou X, Ding Y, Kong L, Wang X, Wang Y, Li J, Song CP, Wang B, Yang S, Zhu JK, Gong Z* (2018) EAR1 negatively regulates ABA signaling by enhancing 2C protein phosphatase activity. Plant Cell 30: 815-834.
19. Li H, Ding Y, Shi Y, Zhang X, Zhang S, Gong Z, Yang S* (2017) MPK3- and MPK6-mediated ICE1 phosphorylation negatively regulates ICE1 stability and freezing tolerance in Arabidopsis. Dev Cell 43: 630-642. (Highlighted with a Preview article in Dev Cell and a Spotlight article in Trends Plant Sci; Selected for F1000 Prime; 植物学报热点评)
20. Liu Z, Jia Y, Ding Y, Shi Y, Zhang X, Li Z, Guo Y, Gong Z, Yang S* (2017) Plasma membrane CRPK1-mediated phosphorylation of 14-3-3 proteins induces their nuclear import to fine-tune CBF signaling during cold response. Mol Cell 66: 117-128. (Highlighted with a Preview article in Mol Cell; Selected for F1000 Prime)
21. Zhang Z#, Li J#, Pan Y#, Li J#, Zhou L#, Shi H#, Zeng Y#, Guo H, Yang S, Zheng W, Yu J, Sun X, Li G, Ding Y, Ma L, Shen S, Dai L, Zhang H, Yang S, Guo Y, Li Z* (2017) Natural variation in CTB4a enhances rice adaptation to cold habitats. Nat Commun 8:14788. (Highly cited in ESI)
22. Zhang Y#, Wang Y#, Liu J, Ding Y, Wang S, Zhang X, Liu Y, Yang S* (2017) Temperature-dependent autoimmunity mediated by chs1 requires its neighboring TNL gene SOC3. New Phytol 213:1330-1345.
23. Jia Y, Ding Y, Shi Y, Zhang X, Gong Z, Yang S* (2016) The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis. New Phytol 212: 345-353. (Highlighted with a Commentary article in New Phytol; Highly cited in ESI)
24. Yu F, Lou L, Tian M, Li Q, Ding Y, Wu Y, Belda-Palazon B, Rodrigue P L, Yang S, Xie Q* (2016) ESCRT-I component VPS23A affects ABA signaling by recognizing ABA receptors for endosomal degradation. Mol Plant 9: 1570-1582.
25. Ding Y, Li H, Zhang X, Xie Q, Gong Z, Yang S* (2015) OST1 kinase modulates freezing tolerance by enhancing ICE1 stability in Arabidopsis. Dev Cell 32: 278-289. (Highlighted with a Preview article in Dev Cell; Highlighted with an article in SCIENCE CHINA Life Sciences; 植物学报热点评; Highly cited in ESI)
26. Kong L, Cheng J, Zhu Y, Ding Y, Meng J, Chen Z, Xie Q, Guo Y, Li J, Yang S, Gong Z* (2015) Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases. Nat Commun 6: 8630. (Highly cited in ESI)
27. Shi Y#, Ding Y#, Yang S* (2015) Cold signal transduction and its interplay with phytohormones during cold acclimation. Plant Cell Physiol 56: 7-15. (Highly cited in ESI)
