实验室围绕植物作物响应逆境胁迫中关键蛋白质的结构与功能开展研究，结合生物化学与分子生物学等方法，阐明这些蛋白的功能和活性调节的分子机制，为植物高效抗逆及品种改良提供育种线索。

      1. Gao, R., Jia, Y., Xu, X., Fu, P., Zhou, J., Yang, G*. (2024). Structural insights into the Oryza sativa cation transporters HKTs in salt tolerance. J Integr Plant Biol, 66(4), 700-708. (*Corresponding author)

2.  Gao, X., Xu, X., Sun, T., Lu, Y., Jia, Y., Zhou, J., …Yang, G*. (2024). Structural changes in the conversion of an Arabidopsis outward-rectifying K+ channel into an inward-rectifying channel. Plant Commun. (*Corresponding author)

3. Zhang, Y., Zhou, J., Ni, X., Wang, Q., Jia, Y., Xu, X., …Yang, G*. (2023). Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt toler  ance. Nature Plants. 9(11), 1915-1923(*Corresponding author)

4. Jia, Y., Zhang, Y., Wang, W., Lei, J., Ying, Z., Yang, G*. (2024). Structural and functional insights of the human peroxisomal ABC transporter ALDP. Elife, 11, e75039. (*Corresponding author)

5.  Lu, Y., Yu, M., Jia, Y., Yang, F., Zhang, Y., Xu, X., …Yang, G*. (2022) Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis. Nat Commun, 13(1), 5682              (*Corresponding author）

6. Zhou, R., Yang, G*., & Shi, Y. (2020). Macromolecular complex in recognition and proteolysis of amyloid precursor protein in Alzheimer’s disease. Current Opinion in Structural Biology, 61, 1-8. (*Corresponding author)

7. Zhou, R., Yang, G*., Guo, X., Zhou, Q., Lei, J., & Shi, Y. (2019). Recognition of the amyloid precursor protein by human γ-secretase. Science, 363(6428), eaaw0930. (*Co-first author)

8. Yang, G., Zhou, R., Zhou, Q., Guo, X., Yan, C., Ke, M., ... & Shi, Y. (2019). Structural basis of Notch recognition by human γ-secretase. Nature, 565(7738), 192.

9. Zhou, R., Yang, G*., & Shi, Y. (2017). Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization. Proceedings of the National Academy of Sciences, 114(48), 12731-12736. (*Co-first author)

10. Yang, G., Zhou, R., & Shi, Y. (2017). Cryo-EM structures of human γ-secretase. Current opinion in structural biology, 46, 55-64.

11. Yu, X., Yang, G*., Yan, C., Baylon, J. L., Jiang, J., Fan, H., ... & Yan, N. (2017). Dimeric structure of the uracil: proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters. Cell research, 27(8), 1020. (*Co-first author and corresponding author)

12. Sun, L., Zhou, R., Yang, G., & Shi, Y. (2017). Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase. Proceedings of the National Academy of Sciences, 114(4), E476-E485.

13. Bai, X. C., Rajendra, E., Yang, G., Shi, Y., & Scheres, S. H. (2015). Sampling the conformational space of the catalytic subunit of human γ-secretase. Elife, 4, e11182.

14. Bai, X. C., Yan, C., Yang, G*., Lu, P., Ma, D., Sun, L., ... & Shi, Y. (2015). An atomic structure of human γ-secretase. Nature, 525(7568), 212. (*Co-first author)

15. Sun, L., Zhao, L., Yang, G*., Yan, C., Zhou, R., Zhou, X., ... & Shi, Y. (2015). Structural basis of human γ-secretase assembly. Proceedings of the National Academy of Sciences, 112(19), 6003-6008. (*Co-first author)

16. Xie, T., Yan, C., Zhou, R., Zhao, Y., Sun, L., Yang, G., ... & Shi, Y. (2014). Crystal structure of the γ-secretase component nicastrin. Proceedings of the National Academy of Sciences, 111(37), 13349-13354.

17. Lu, P., Bai, X.C., Ma, D., Xie, T., Yan, C., Sun, L., Yang, G., Zhao, Y., Zhou, R., Scheres, S.H. and Shi, Y. (2014). Three-dimensional structure of human γ secretase. Nature, 512(7513), 166.